Evaluation of Corneal Sensitivity in Patients with Multiple Sclerosis and Parkinson’s Disease
DOI:
https://doi.org/10.70670/sra.v4i1.2621Keywords:
Multiple Sclerosis, Parkinson’s Disease, Corneal Sensitivity, Cochet-Bonnet Esthesiometer, Neurodegeneration, Disease DurationAbstract
Multiple Sclerosis (MS) and Parkinson’s Disease (PD) are neurodegenerative disorders that may affect corneal innervation and sensory function. Corneal sensitivity assessment provides a simple, non-invasive method for evaluating neurological involvement in these conditions. To evaluate corneal sensitivity in patients with Multiple Sclerosis and Parkinson’s Disease, and to determine the relationship between disease duration and corneal sensitivity in patients with Multiple Sclerosis and Parkinson’s Disease. This cross-sectional observational study was conducted at the Department of Ophthalmology, Services Hospital Lahore, and Social Security Teaching Hospital Lahore in collaboration with the Department of Neurology. A total of 58 participants were enrolled, including 29 patients with MS and 29 patients with PD. Corneal sensitivity was measured using the Cochet-Bonnet esthesiometer in both eyes, and the mean value was used for analysis. Normality was assessed using the Shapiro–Wilk test. One-way ANOVA with Bonferroni post-hoc test, Kruskal–Wallis test, Spearman correlation, and Mann–Whitney U test were applied as appropriate. A p-value < 0.05 was considered significant. A total of 58 participants were included, comprising 29 patients with Multiple Sclerosis (MS) and 29 patients with Parkinson’s Disease (PD). Mean corneal sensitivity was 54.01 ± 3.23 mm in the Multiple Sclerosis group and 52.96 ± 3.85 mm in the Parkinson’s disease group. Corneal sensitivity decreased significantly with increasing disease duration in Multiple Sclerosis patients (p = 0.010; ρ = −0.373, p = 0.047), whereas no significant association was observed in Parkinson’s disease patients (p = 0.218; ρ = −0.195, p = 0.310). Corneal sensitivity decreased significantly with disease duration in Multiple Sclerosis but not in Parkinson’s disease. Corneal sensitivity assessment may serve as a useful non-invasive marker of disease progression in Multiple Sclerosis.
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