Development of New Spectrophotometric Method to Determination of Gabapentin in Pharmaceutical Dosage Using Trifluoroacetylacetone as a Reagent
DOI:
https://doi.org/10.70670/sra.v4i2.2067Abstract
Spectrophotometric method has been developed for the determination of gabapentin after derivatization with trifluoroacetylacetone (TFAA). The linear calibration curve was obtained within 10-60 µg/ml and detection was at 290nm. The relative deviation (RSD) of gabapentin was determined 0.5% with a correlation coefficient of 0.998. The LOD and LOQ were determined 5 µg/ml and 6 µg/ml respectively. The innovative developed method has been applied effectively for the analysis of gabapentin from tablets obtained from local markets and the exact amounts found from tablet were examined 98 and 19 mg/tablet. The recovery percentage 99% of gabapentin was found from pharmaceutical preparation.
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